Loperamide: studies on its mechanism of action.

Loperamide: studies on its mechanism of action.

The effects of loperamide on net solute and water absorption, and prostaglandin E2 (PGE2) and cholera toxin-induced secretion were studied in the rat jejunum using an in vivo steady-state perfusion technique. Loperamide stimulated absorption of fluid, electrolytes, and glucose and reversed PGE2 and cholera toxin-induced secretion to absorption; this opiate analogue had no effect on cholera toxi...

Study of Basil (Ocimum basilicum L) and its Mechanism of Action on Type 2 Diabetes

Introduction: Diabetes mellitus is a chronic metabolic disease with life threatening complications such as diabetic retinopathy, renal failure and cardiovascular disease. Metformin, Glibenclamide, Acarbose, Empagliflozin, Sitagliptin and Repaglinide are the most common drugs for reducing the blood glucose. The blood glucose-lowering drugs have side effects such as severe hypoglycemia, liver cel...

Mechanism of Action of the Thyroid Hormone on the Heart

SUMMARY  The foliowing cardiac effects may be at­tributed to thyroxin:  1-Thyroxin augments all anaerobic pro­cesses in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...

Studies on the Mechanism of Interferon Action

Interferon does not inactivate viruses or viral RNA. Virus growth is inhibited in interferon-treated cells, but apart from conferring resistance to virus growth, no other effect of interferon on cells has been definitely shown to take place. Interferon binds to cells even in the cold, but a period of incubation at 37 degrees C is required for development of antiviral activity. Cytoplasmic uptak...

Studies on the mechanism of hormone action.